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Acute cardiac effects of high dose steroid treatment: A speckle tracking echocardiography study
Author(s) -
Aksakal Emrah,
Simsek Ziya,
Aksu Uğur,
Birdal Oguzhan,
Ateş Esma Selva,
Kalkan Kamuran,
Gulcu Oktay,
Demirelli Selami,
Aksakal Enbiya,
Tas Hakan
Publication year - 2019
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22716
Subject(s) - medicine , speckle tracking echocardiography , cardiac function curve , cardiology , ejection fraction , heart failure
Purpose High‐dose steroid therapy (HDST) has frequent side‐effects that appear at its cessation and depend on its dose. However, there is a lack of studies about the acute effects of HDST on cardiac function in adult patients. Methods We included in this study 30 patients who underwent HDST (intravenously at doses ranging from 250 to 1000 mg) and 30 healthy control subjects with similar demographic and clinical characteristics, between September and December 2016. Echocardiographic measurements were made before and during the first 3 hours after the end of treatment, and results were compared between patients and controls. Results There was no difference in baseline biochemical and echocardiographic characteristics between the patient and control groups. While left ventricular global longitudinal strain (LVGLS) and strain rate E were higher after treatment, no significant change was observed in conventional echocardiographic variables. Conclusions LVGLS, but not conventional echocardiographic variables, showed an increase in cardiac systolic function at the acute phase of HDST.