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Effects of bone marrow mononuclear cells delivered through a graft vessel in patients with previous myocardial infarction and chronic heart failure: An echocardiographic study of left ventricular dyssynchrony
Author(s) -
Qi Zhi,
Liu Sheng,
Duan Fujian
Publication year - 2018
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22609
Subject(s) - medicine , cardiology , myocardial infarction , heart failure , artery , bone marrow , ischemic cardiomyopathy , ejection fraction
Objectives Several trials are investigating the delivery of stem cells to treat ischemic cardiomyopathy. The aim of this study was the echocardiographic evaluation of the effectiveness of isolated coronary artery bypass graft (CABG) combined with bone marrow mononuclear cells (BMMNC) delivered through the graft vessels to improve left ventricular dyssynchrony in patients with previous myocardial infarction and chronic heart failure. Methods 42 patients with previous myocardial infarction and chronic heart failure were randomly allocated to either the CABG only group ( n = 18) or the CABG with BMMNC graft group ( n = 24group). We used 2D strain imaging to measure the absolute difference in time‐to‐peak radial strain between the earliest and the latest activated segments on LV short‐axis images at the apical (RSTa), at the mitral annulus (RSTb), and at the papillary muscle (RSTm) level. Results The effective rate of LV dyssynchrony improvement was significantly higher in the CABG + BMMNC than in the CABG only group (RSTb: 91.7% vs 50%, P < .05; RSTm: 78.6% vs 35.7%, P < .05; RSTa: 92.3% vs 50%, P < .05). The deterioration rate of LV synchrony was significantly lower in the CABG + BMMNC than in the CABG only group for RSTb (8.3% vs 70%, P < .05;) and RSTm (0 vs 50%, P < .05), but not for RSTa (18.2% vs 37.5%, P > .05). Conclusions Combining CABG with BMMNC delivering provided a better improvement of left ventricular dyssynchrony than CABG only.