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Left ventricular twist is impaired in acromegaly: Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study
Author(s) -
Kormányos Árpád,
Domsik Péter,
Kalapos Anita,
Orosz Andrea,
Lengyel Csaba,
Valkusz Zsuzsanna,
Trencsányi Attila,
Forster Tamás,
Nemes Attila
Publication year - 2018
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22529
Subject(s) - acromegaly , medicine , speckle tracking echocardiography , basal (medicine) , twist , cardiology , transsphenoidal surgery , speckle pattern , adenoma , endocrinology , gastroenterology , pituitary adenoma , hormone , growth hormone , heart failure , ejection fraction , geometry , mathematics , artificial intelligence , insulin , computer science
Abstract Introduction Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age‐ and gender‐matched healthy controls. Methods The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age‐ and gender‐matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). Results In 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so‐called LV “rigid body rotation” (RBR). Between all acromegalic patients without LV‐RBR and controls, both LV basal (–3.76 ± 1.73 vs. −6.17 ± 2.66°, P = .004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P = .001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P < .001) differed significantly. Between active and nonactive acromegaly subgroups, only the time‐to‐peak LV twist (377 ± 78 vs. 229 ± 97 ms, P = .005) showed significant difference. Conclusions Acromegaly is associated with impaired LV rotation and twist as assessed by 3‐dimensional speckle tracking echocardiography. LV‐RBR is a frequent phenomenon in acromegaly.