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Comparison of contrast‐enhanced ultrasonography with virtual touch tissue quantification in the evaluation of focal liver lesions
Author(s) -
Wu Jingping,
Shu Rui,
Zhao Yuzhen,
Ma Guolin,
Xue Wei,
He Qijia,
Hao Meina,
Liu Yawu
Publication year - 2016
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22335
Subject(s) - medicine , ultrasonography , ultrasound , contrast enhanced ultrasound , radiology , predictive value , diagnostic accuracy , cutoff , significant difference , nuclear medicine , physics , quantum mechanics
Purpose To evaluate the diagnostic efficacy of virtual touch tissue quantification (VTQ) and contrast‐enhanced ultrasonography (CEUS), separately and in combination, in diagnosing malignant focal liver lesions (FLLs). Methods Forty‐six patients with 55 FLLs (28 benign and 27 malignant) underwent both VTQ and CEUS. The diagnostic values of VTQ and CEUS, alone and in combination, were compared. Results The diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of CEUS were 92.6% (25/27), 96.4% (27/28), 94.5% (52/55), 96.2% (25/26), and 93.1% (27/29), respectively. The diagnostic sensitivity, specificity, accuracy, PPV, and NPV of VTQ with a cutoff of 2.22 m/s were 51.9% (14/27), 85.7% (24/28), 69.1% (38/55), 77.8% (14/18), and 64.9% (24/37), respectively. The diagnostic sensitivity, specificity, accuracy, PPV, and NPV of VTQ and CEUS combined were 96.3% (26/27), 82.1% (23/28), 89.1% (49/55), 83.9% (26/31), and 95.8% (23/24), respectively. Comparing the accuracies of the three methods, the diagnostic values of CEUS and of the combination of CEUS with VTQ were significantly higher than those of VTQ alone ( p ≤ 0.01). There was no significant difference between the combination of CEUS with VTQ and CEUS ( p = 0.49). Conclusions CEUS is superior to VTQ in diagnosing malignant FLLs. Adding VTQ to CEUS did not improve the diagnosis of FLLs. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44 :347–353, 2016