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Carotid artery diameter and wall stiffness in proteinuric renal disease without severely reduced kidney function
Author(s) -
Iannuzzi MariaRosaria,
D'Angelillo Antonio,
Tortori Antonia,
Pazzano Dario,
De Serio Luca,
Covetti Giuseppe,
Bresciani Alessandro,
Iannuzzi Arcangelo
Publication year - 2015
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22292
Subject(s) - medicine , renal function , proteinuria , urology , kidney disease , nephropathy , albuminuria , glomerulonephritis , focal segmental glomerulosclerosis , lupus nephritis , cardiology , gastroenterology , kidney , endocrinology , disease , diabetes mellitus
Purpose To evaluate the carotid artery diameter, and wall thickness and stiffness in patients with glomerulopathy and proteinuria without severely reduced kidney function. Methods We compared 30 control subjects to 30 patients with glomerular disease, proteinuria, and glomerular filtration rate > 30 ml/min/1.73 m 2 : membranous glomerulonephritis (n = 13), minimal change disease (n = 2), focal and segmental glomerulosclerosis (n = 3), IgA nephropathy (n = 5), lupus nephritis (n = 5), antiphospholipid antibody nephropathy (n = 1), cryoglobulinemic glomerulonephritis (n = 1). The laboratory evaluations included carotid artery diameter, intima‐media thickness, and stiffness measurements. Results Carotid cross‐sectional area of intima‐media complex was thicker in patients (18.6 ± 1.4 [x ± SEM]) than in controls (14.8 ± 0.6 mm 2 , p = 0.014), as was carotid artery wall stiffness (8.96 ± 0.86 versus 5.65 ± 0.38, [x ± SEM], p < 0.01). This difference remained significant after adjustment for age, sex, and metabolic cardiovascular risk factors: carotid stiffness was 9.19 ± 0.67 (99% confidence interval [CI] 7.40–10.98)] in patients and 4.80 ± 0.75 (99% CI 2.79–7.11) in controls; adjusted mean difference 4.40 (99% CI 1.46–7.34); p < 0.001. Conclusions This study showed, for the first time, signs of altered structural and elastic properties of the arterial wall in patients with proteinuria and glomerular disease without severely reduced kidney function. © 2015 Wiley Periodicals, Inc. J Clin Ultrasound 44 :175–181, 2016