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Effect of metformin treatment on endometrial vascular indices in anovulatory obese/overweight women with polycystic ovarian syndrome using three‐dimensional power doppler ultrasonography
Author(s) -
Mohsen Iman Abdel,
Elkattan Eman,
Nabil Hala,
Khattab Sherif
Publication year - 2013
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22006
Subject(s) - medicine , metformin , polycystic ovary , anovulation , body mass index , gynecology , uterine artery , ovulation , overweight , obstetrics , pregnancy , insulin resistance , obesity , insulin , hormone , gestation , biology , genetics
Purpose Metformin has been shown to be an effective treatment for anovulatory polycystic ovary syndrome (PCOS) patients in terms of menstrual cyclicity, ovulation, and pregnancy, as well as reduction of early miscarriage rate. The aim of the study is to assess the effect of metformin on the endometrial vascular indices in anovulatory obese PCOS women using three‐dimensional power Doppler sonography (3DPDUS). Methods A prospective study was set to determine the beneficial effects of metformin on PCOS patients. Fifty anovulatory obese PCOS patients were compared with another 50 healthy volunteers who were age‐ and body mass index‐matched (control group). PCOS patients were treated with metformin (Glucophage; MerckSerono) 850 mg 3 times a day for 6 months. Assessment of the endometrial thickness and volume, uterine Doppler indices, and Doppler vascular indices of the endometrium and subendometrium in the periovulatory and midluteal phases were performed with 3DPDUS. Results There was a significant increase in the endometrial thickness, endometrial volume, and endometrial and subendometrial vascularity indices (vascularization index, flow index, vascularization flow index) after 6 months of metformin treatment in PCOS women, whereas there was no change in the resistance index and the pulsatility index of the uterine artery in both periovulatory and midluteal phases. Conclusions Metformin, owing to its metabolic, endocrine, vascular, and anti‐inflammatory effects, improves markers of endometrial receptivity. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 41:275–282, 2013