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Vascular risk in women with a history of severe preeclampsia
Author(s) -
Goynumer Gokhan,
Yucel Nese,
Adali Ertan,
Tan Temel,
Baskent Erdem,
Karadag Cihan
Publication year - 2012
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.21962
Subject(s) - medicine , preeclampsia , insulin resistance , intima media thickness , brachial artery , ultrasonography , family history , pregnancy , diabetes mellitus , obstetrics , disease , ultrasound , endothelial dysfunction , vascular disease , risk factor , cardiology , carotid arteries , insulin , endocrinology , surgery , blood pressure , radiology , genetics , biology
Abstract Background. To assess markers of vascular dysfunction and risk in postpartum women with a history of severe preeclampsia. Methods. Carotid intima‐media thickness (CIMT) and brachial artery flow‐mediated dilatation (FMD) measured by ultrasonography, and lipid profile and insulin resistance evaluated by biochemical assays were compared between 34 women with a history of severe preeclampsia and 42 women with a prior normal pregnancy at least 12–24 months postpartum. Results. CIMT was higher and FMD lower in the preeclamptic than in the control group. We found a significant inverse correlation between CIMT and FMD in the preeclamptic group, but no difference in lipid profiles and insulin resistance between the groups. Conclusions. Women with a history of severe preeclampsia exhibit early structural and functional preatherosclerotic vascular impairment, which might explain their higher risk of future cardiovascular disease. © Wiley Periodicals, Inc. J Clin Ultrasound, 2013