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Prediction of abortion using three‐dimensional ultrasound volumetry of the gestational sac and the amniotic sac in threatened abortion
Author(s) -
Odeh Marwan,
Ophir Ella,
Grinin Vitaly,
Tendler Rene,
Kais Mohamad,
Bornstein Jacob
Publication year - 2012
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.21957
Subject(s) - medicine , gestational sac , gestation , abortion , gestational age , obstetrics , pregnancy , gynecology , amniotic sac , ultrasound , fetus , medical abortion , vaginal bleeding , 3d ultrasound , amniotic fluid , radiology , misoprostol , genetics , biology
Purpose. To determine whether gestational sac volume (GSV) or amniotic sac volume (ASV) and/or the difference between them can predict abortion in women with first‐trimester threatened abortion. Methods. Ninety patients between 6 and 12 weeks of gestation presenting with vaginal bleeding were studied. Seventy‐six delivered after 24 weeks of gestation (group A) and 14 aborted before 20 weeks of gestation (group B). All patients had a singleton viable pregnancy demonstrated by transvaginal ultrasound. Gestational sac and amniotic sac volumes were measured in all the patients using three‐dimensional transvaginal ultrasound with Virtual Organ Computer‐aided Analysis software, and the gestational sac volume − amniotic sac volume (GSV − ASV) was calculated. Results. The groups did not differ in terms of age, parity, number of previous abortions, or term deliveries. The GSV (group A: mean 32.0 ± 27.7 cm 3 ; group B: 26.7 ± 29.1 cm 3 ) and the ASV (group A: 21.1 ± 25.5 cm 3 ; group B: 20.6 ± 26.0 cm 3 ) were not statistically different, while the GSV − ASV was significantly smaller in group B (aborting before week 20) (group A: 10.9 ± 10.9 cm 3 ; group B: 6.1 ± 8.6 cm 3 ; p < 0.05). Using receiver operator curves, the area under the curve for predicting normal pregnancy outcome of the GSV − ASV measurement was 0.654. When the GSV − ASV was 1.8 cm 3 or less, abortion was predicted with 84% sensitivity and 43% specificity. Conclusions. The measurement of the GSV and the ASV are not good predictors of abortion in patients with first‐trimester vaginal bleeding, whereas the use of the GSV − ASV may be helpful in predicting the outcome of pregnancy. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound 40:389–393, 2012

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