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Stepwise sequential aneuploidy screening in clinical practice
Author(s) -
Wax Joseph R.,
Cartin Angelina,
Smith Dwight,
Smith Rosemarie,
Chard Renée,
Carpenter Molly,
Pinette Michael G.
Publication year - 2012
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.20898
Subject(s) - medicine , nuchal translucency measurement , aneuploidy , trisomy , nuchal translucency , clinical practice , prenatal diagnosis , obstetrics , cystic hygroma , prenatal screening , pediatrics , gynecology , pregnancy , fetus , family medicine , genetics , chromosome , gene , biology
Purpose. To evaluate stepwise sequential screening (SSS) efficiency in clinical practice. Methods. All singletons undergoing SSS in a single practice by NTQR (Nuchal Translucency Quality Review Program)‐credentialed providers in a 2‐year period were included. Prenatal diagnosis was offered to all screen‐positive women and those with a nuchal translucency ≥3.5 mm or cystic hygroma at the 11‐ to 14‐week scan. Data were extracted from prospectively ascertained serum screening and genetics databases. Results. A total of 2,726 patients were screened, with SSS detecting all eight cases of trisomy 21 and all seven cases of other aneuploidies at a 4.3% screen‐positive rate. Conclusions. Stepwise sequential screening offers excellent aneuploidy screening efficiency when introduced into clinical practice. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011