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Value of contrast‐enhanced sonography with micro flow imaging in the diagnosis of prostate cancer
Author(s) -
Xie Shao Wei,
Li Feng Hua,
Li Hong Li,
Du Jing,
Xia Jian Guo,
Fang Hua,
Bo Juan Jie,
Zhu Jian Shan
Publication year - 2011
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.20841
Subject(s) - medicine , prostate cancer , prostate , biopsy , predictive value , cancer , pathology , radiology , positive predicative value , urology
Background. To evaluate the effectiveness of contrast‐enhanced sonographic micro flow imaging (MFI) in the diagnosis of prostate cancer. Methods. A total of 74 patients referred for prostate biopsy were prospectively evaluated with MFI. The abnormalities were categorized into four patterns: pattern 1: indistinct separation between the inner and outer gland; pattern 2: asymmetrical or focally increased enhancement in the outer gland; pattern 3: enhancement with focal defect; pattern 4: enhancement in the outer gland equal to that of the inner gland. The findings were correlated with Gleason scores. Results. Prostate cancer was detected in 264 sites in 41 patients. The sensitivity, specificity, accuracy, and positive and negative predictive values for MFI were 81.1%, 84.3%, 83.3%, 68.6%, and 91.3%, respectively. Positive predictive values for the four patterns were 46.0 (pattern 1), 53.6 (pattern 2), 94.3 (pattern 3), and 95.4 (pattern 4). Gleason scores of cancers with patterns 3 (7.09) or 4 (7.51) were significantly higher than those with patterns 1 (6.17) or 2 (6.59) ( p = 0.001, p = 0.005, p < 0.001, p < 0.001). Conclusions. Some MFI patterns had high positive predictive values and were associated with more aggressive cancers. This could be used to reduce the number of biopsy sites and detect clinically significant cancers. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011