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Prenatal diagnosis of trisomy 16 mosaicism manifested as pulmonary artery stenosis
Author(s) -
Hidaka Nobuhiro,
Yamamoto Nari,
Tsukimori Kiyomi,
Hojo Satoshi,
Suzuki Satoshi O.,
Wake Norio
Publication year - 2009
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.20499
Subject(s) - amniocentesis , medicine , trisomy , prenatal diagnosis , fetus , single umbilical artery , aneuploidy , obstetrics , stenosis , fetoscopy , pregnancy , radiology , genetics , chromosome , biology , gene
Trisomy 16 mosaicism detected at midtrimester amniocentesis is rare and indicative of true fetal mosaicism. We report a case of mosaic trisomy 16 diagnosed by amniocentesis in which the sonographic findings included fetal pulmonary artery stenosis, a single umbilical artery, and early onset fetal growth restriction. The pregnancy was legally terminated. A review of previous reports suggests that abnormalities of outlet tracts are rarely encountered in fetuses with trisomy 16 mosaicism revealed via amniocentesis. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2009