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Diffuse leukoencephalopathy: Unusual sonographic finding in an infant with mitochondrial disease
Author(s) -
Hung PoCheng,
Wang HueiShyong
Publication year - 2007
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.20315
Subject(s) - leukoencephalopathy , medicine , white matter , pathology , brainstem , mitochondrial dna , mitochondrial disease , basal ganglia , leukodystrophy , disease , magnetic resonance imaging , central nervous system , radiology , biology , genetics , gene
Several mitochondrial diseases are known to occasionally involve the cerebral white matter, but in these cases the major findings are involved in the basal ganglia and brainstem. We report a case of diffuse white matter involvement in an infant with mitochondrial disease that was diagnosed via mitochondrial DNA analysis. Mitochondrial disease should be considered in the diagnosis of diffuse leukoencephalopathy in infancy. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2007