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Unusual sonographic appearance of a gastrointestinal stromal tumor presenting as a large multilocular cystic mass
Author(s) -
Chang ChiYang,
Wang HsiuPo,
Mao TasuiLien,
Hu ReyHeng,
Yang PeiMing,
Lai MingYang,
Lin JawTown
Publication year - 2004
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.20010
Subject(s) - gist , medicine , stromal tumor , lesion , imatinib mesylate , stomach , radiology , abdomen , pathology , cd34 , laparotomy , stromal cell , imatinib , genetics , stem cell , myeloid leukemia , biology
Cystic change is uncommon in gastrointestinal stromal tumor, (GISTs). This report describes 1 case in which a GIST presented as a large multilocular cystic mass. Sonography of the abdomen showed a huge cystic lesion with multiple septa in the left upper quadrant of the abdomen, compressing the left lobe of the liver. Esophagogastroscopy showed only a small submucosal tumor at the anterior wall of the mid portion of the gastric body. Endoscopic sonography revealed a hypoechoic mass, measuring 0.9 × 0.7 cm, arising from the fourth layer of the anterior wall of the mid portion of the gastric body. A huge cystic tumor, containing multiple septa and continuous with the small submucosal lesion, was found. Doppler signals were detected within the septa. Laparotomy revealed a huge exophytic cystic tumor arising from the stomach. Immunohistochemical analysis confirmed that the lesion was a GIST by detecting expression of the c‐kit and CD34 proteins. GIST that has undergone cystic change must be differentiated from other cystic lesions to guide the treatment approach. Imatinib mesylate is a new therapeutic alternative for patients who have advanced GIST, but surgery remains the therapy of choice for resectable disease. © 2004 Wiley Periodicals, Inc. J Clin Ultrasound 32:200–203, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/jcu.20010