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Value of serum alkaline phosphatase in evaluating hyperplasia of parathyroid glands in chronic hemodialysis patients
Author(s) -
Huang YuYao,
Hsu Brend RaySea,
Huang BieYu,
Huang HongSo,
Huang MiauJu
Publication year - 1994
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.1870220309
Subject(s) - medicine , alkaline phosphatase , parathyroid hormone , hyperparathyroidism , hyperplasia , secondary hyperparathyroidism , hemodialysis , endocrinology , elevated alkaline phosphatase , parathyroid gland , calcium , chemistry , enzyme , biochemistry
To investigate the value of serum alkaline phosphatase in evaluating hyperplasia of parathyroid glands in hemodialysis patients, 28 hemodialysis patients who had parathyroid sonography examinations for secondary hyperparathyroidism were studied retrospectively. There were significant elevations of serum alkaline phosphatase, parathyroid hormone (PTH), serum total calcium, and dialysis duration in patients with sonography‐detectable parathyroid ( N = 17) as compared with those of sonography‐undetectable ( N = 11) parathyroid. Hemodialysis patients who have both higher serum alkaline phosphatase (>94 IU/ L) and considerably elevated serum PTH (9× or higher) are likely to have sonography‐detectable parathyroids (positive predictive value of 93%). Patients with mildly or moderately elevated serum PTH but normal serum alkaline phosphatase are less likely to have sonography‐detectable parathyroids (negative predictive value is 100%). These findings suggest that the elevation of serum alkaline phosphatase could be a valuable parameter in addition to the high serum PTH level in predicting hyperplasia of parathyroid glands in chronic hemodialysis patients. © 1994 John Wiley & Sons, Inc.