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Transabdominal ultrasonographic evaluation of endometrial thickness in clomiphene citrate‐stimulated cycles in relation to conception
Author(s) -
Wolman Igal,
Sagi Joseph,
Pauzner David,
Yovel Israel,
Seidman Daniel S.,
David Menachem P.
Publication year - 1994
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.1870220207
Subject(s) - medicine , relation (database) , gynecology , radiology , computer science , database
The possible antiestrogenic effect of clomiphene citrate on endometrial growth was assessed by serial transabdominal ultrasonographic measurements in 46 women with unexplained infertility. A significantly higher ( p < 0.05) rate of endometrial growth was observed in the 8 women who conceived compared with the 38 women who failed to conceive. A thicker endometrium (4.6 ± 0.3 mm) was observed from the third day before ovulation as well as a higher average growth rate in the three days prior to ovulation (0.7 ± 0.1 mm/day) in the group that achieved pregnancy compared to a lower endometrium (2.1 ± 0.2 mm) from the third day before ovulation and a slower growth rate in the three days prior to ovulation (0.2 ± 0.0 mm/day) in the group that did not achieve pregnancy ( p < 0.05). These data suggest that clomiphene citrate may exert an antiestrogenic effect on the endometrium, and thus interfere with implantation. © 1994 John Wiley & Sons, Inc.