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Is the corpus luteum normal after ovulation induction?
Author(s) -
Lenz Suzan,
Lindenberg Svend
Publication year - 1990
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.1870180303
Subject(s) - corpus luteum , luteal phase , ovulation , luteinizing hormone , medicine , endocrinology , gonadotropin , human chorionic gonadotropin , follicle , ovulation induction , menstrual cycle , andrology , ovarian follicle , hormone
Repeated ultrasound examinations and blood samplings for determination of estradiol (E), progesterone (P), and luteinizing hormone (LH) were carried out in 15 normal and 11 clomiphene citrate (CC)/human menopausal gonadotropin (hMG) stimulated cycles. Human chorionic gonadotropin (hCG) was administered in the stimulated cycles on the day of the expected LH‐peak as determined in each woman's normal cycle. Ovulation and normalcy of the luteal phase were confirmed by the hormonal values. Ultrasound examinations showed development of a single follicle in the normal group and development of 4.1 follicles on average, of 15 mm or more in diameter in the stimulated group (total of 45 follicles). Midluteal phase images at the site of the former follicle showed echogenic structures or echo‐free structures with scattered echoes in 25 cases in the stimulated group and in 11 cases in the normal group. There was no sign of the former follicle in 1 and 3 cases, respectively, in the two groups. A significantly higher number of “persistent follicles” was seen in the stimulated group: 42% vs. 7%. It is discussed whether a compromized corpus luteum function occurs after stimulation despite a normal luteal phase.