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Ultrasound does not affect human lymphocyte transformation in vitro
Author(s) -
Katoh Arthur K.,
Charoensiri Surin
Publication year - 1983
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.1870110603
Subject(s) - pokeweed mitogen , concanavalin a , medicine , lymphocyte , lymphocyte activation , ultrasound , immunology , in vitro , in vivo , thymidine , transformation (genetics) , immune system , biology , t cell , radiology , biochemistry , microbiology and biotechnology , gene
The lymphocyte transformation test has been used in testing the effect of ultrasound on human lymphocytes. The test utilizes the mitogenic lectins, phytohemagglutinin, concanavalin A, and pokeweed mitogen to stimulate the incorporation of 3 H‐thymidine into resting lymphocytes after several days in culture. Ultrasound, which is increasingly used in diagnostic radiology, has been reported as an immunosuppressive agent in mice. Lymphocyte transformation has been used clinically as a test measuring the effectiveness of immunoenhancing and immunosuppressive therapies. The experiments reported here do not demonstrate an immunosuppressive role for ultrasound on human lymphocytes.