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Transplant immunity in hamsters treated with ultrasound
Author(s) -
Hare John D.,
Linke Charles A.,
Child Sally Z.,
Fridd Charlotte W.,
Carstensen Edwin L.,
Davis Henry T.
Publication year - 1982
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.1870100602
Subject(s) - medicine , immunity , ultrasound , hamster , immunology , immune system , radiology
Hamsters with subcutaneous fibrosarcomas were treated by excision and by exposure to 5‐MHz ultrasound for six minutes at an intensity of 3 W/sq cm. Rates for successful elimination of the tumors were between 80% and 90% and were not significantly different for the two methods of treatment. After 30 days, the animals were challenged with the same tumor cells. Animals successfully treated with ultrasound or excision required at least 10 times as many cells to produce a tumor as controls, indicating that eradication of the tumor by ultrasound induced a level of transplant immunity at least as good as that resulting from surgical excision.