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The use of β‐Thromboglobulin to detect platelet damage by therapeutic ultrasound in vivo
Author(s) -
Williams Alun R.,
Chater Bernard V.,
Allen Kenneth A.,
Sanderson Joel H.
Publication year - 1981
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.1870090402
Subject(s) - medicine , platelet , prostacyclin , in vivo , ultrasound , cannula , platelet factor 4 , beta thromboglobulin , radioimmunoassay , platelet activation , endocrinology , andrology , cardiology , surgery , radiology , biology , microbiology and biotechnology
Three sequential blood samples were drawn from arms of adult human volunteers by means of a cannula technique, and the plasma levels of β‐thromboglobulin (β‐TG, an index of platelet damage) were measured. Ultrasound (0.75 MHz, continuous wave; spatially averaged intensity 0.34 to 0.5 W/cm –2 ) was applied to the blood vessels while the second sample of each series was being taken. No elevation of β‐TG was detected, indicating that under these conditions ultrasonic irradiation had not damaged an appreciable number of platelets. There was, however, an indication of decreased platelet sensitivity following insonation; and it is postulated that this may be the result of either increased production or secretion of the potent endothelial platelet inhibitor, prostacyclin, or both.