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Validity of sonographic screening for the detection of abdominal cancers
Author(s) -
Mizuma Yoshihiro,
Watanabe Yoshiyuki,
Ozasa Kotaro,
Hayashi Kyohei,
Kawai Keiichi
Publication year - 2002
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.10089
Subject(s) - medicine , asymptomatic , abdominal ultrasound , screening test , cancer , population , radiology , predictive value , cancer screening , gynecology , pediatrics , environmental health
Purpose This study assessed the prevalence of abdominal cancers and the validity of sonographic screening for abdominal cancers in an asymptomatic population. Methods We investigated the findings of the first sonographic screening of 16,024 residents of Osaka Prefecture. A comparison of records was carried out between the list of those screened and the Osaka Cancer Registry to identify false‐negative results of our screening. Results The rate of subjects who required further testing after screening was 4.76% (762/16,024). Eleven of the 762 subjects with a positive sonographic screening study had abdominal cancers detected on further testing. Three subjects had false‐negative screening results. The positive predictive value of sonographic screening was 1.4% (11/762), and the rate of screening‐detected cancers was 0.069% (11/16,024). The prevalence of abdominal cancers was 0.087% (14/16,024), the sensitivity of screening sonography for the detection of abdominal cancers was 78.6% (11/14), and the specificity was 95.3% (15,259/16,010). Seven of 11 screening‐detected cancers were resected curatively, and 6 of these patients are still alive. Five of these 6 cancers were renal cell carcinomas. Conclusions The sensitivity of screening sonography was relatively high and the specificity was sufficient among our asymptomatic population. The present study suggests that the target organ for sonographic screening to detect curable cancers should be the kidneys. © 2002 Wiley Periodicals, Inc. J Clin Ultrasound 30:408–415, 2002