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Cell‐based aqueous two‐phase systems for therapeutics
Author(s) -
GonzálezGonzález Mirna,
RitoPalomares Marco
Publication year - 2020
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.6173
Subject(s) - biocompatibility , polyethylene glycol , nanotechnology , aqueous medium , computer science , biochemical engineering , process (computing) , aqueous solution , chemistry , materials science , engineering , chemical engineering , operating system
Cell‐based aqueous two‐phase system technologies present an emerging and promising translational tool for the development of next‐generation therapeutic applications. Advantages such as biocompatibility, scalability and ease of implementation confirm this possibility. The aim of this perspective article is to present a brief, process‐oriented analysis of cell‐based aqueous two‐phase system strategies for therapeutic purposes, highlighting their potential advantages and limitations. These strategies include regenerative therapies, high‐throughput screening platforms and clinical diagnostics. Special attention is given to the implementation of polyethylene glycol and dextran aqueous two‐phase systems in the culture, expansion and separation of cells to accomplish novel diagnostic and therapeutic tasks for the healthcare, biotechnology and pharmaceutical industries. © 2019 Society of Chemical Industry