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Metabolic strategies for microbial glycerol overproduction
Author(s) -
Lim Chanyuen,
Lin Annette Luhe,
Zhao Hua
Publication year - 2018
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.5465
Subject(s) - glycerol , raw material , production (economics) , overproduction , microbiology and biotechnology , biochemical engineering , fine chemical , productivity , yield (engineering) , chemical industry , sustainable production , chemistry , biochemistry , biology , engineering , economics , organic chemistry , materials science , metallurgy , macroeconomics , enzyme
Glycerol as a platform chemical has wide applications in chemical, pharmaceutical, and food industries and is a useful feedstock for the production of bio‐based chemicals. There is an increasing demand for sustainable glycerol production and microbial glycerol production is a promising alternative. The paper highlighted this new trend and summarized recent research progress on microbial glycerol production, and focused mainly on the efforts achieved in rational design of S. cerevisiae , as well as Escherichia coli , to overcome the limitations of glycerol production in these two microorganisms. More efforts are required for overcoming hurdles in yield and productivity enhancement for large scale production. © 2017 Society of Chemical Industry