Metabolic strategies for microbial glycerol overproduction | Zendy

Lim Chanyuen | Zendy; Lin Annette Luhe | Zendy; Zhao Hua | Zendy

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Metabolic strategies for microbial glycerol overproduction

Author(s) -

Lim Chanyuen,

Lin Annette Luhe,

Zhao Hua

Publication year - 2018

Publication title -

journal of chemical technology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.64

H-Index - 117

eISSN - 1097-4660

pISSN - 0268-2575

DOI - 10.1002/jctb.5465

Subject(s) - glycerol , raw material , production (economics) , overproduction , microbiology and biotechnology , biochemical engineering , fine chemical , productivity , yield (engineering) , chemical industry , sustainable production , chemistry , biochemistry , biology , engineering , economics , organic chemistry , materials science , metallurgy , macroeconomics , enzyme

Glycerol as a platform chemical has wide applications in chemical, pharmaceutical, and food industries and is a useful feedstock for the production of bio‐based chemicals. There is an increasing demand for sustainable glycerol production and microbial glycerol production is a promising alternative. The paper highlighted this new trend and summarized recent research progress on microbial glycerol production, and focused mainly on the efforts achieved in rational design of S. cerevisiae , as well as Escherichia coli , to overcome the limitations of glycerol production in these two microorganisms. More efforts are required for overcoming hurdles in yield and productivity enhancement for large scale production. © 2017 Society of Chemical Industry

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