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Biotransformation of benzaldehyde to L ‐phenylacetylcarbinol ( L ‐PAC) by Torulaspora delbrueckii and conversion to ephedrine by microwave radiation
Author(s) -
Shukla Vilas B,
Madyar Virendra R,
Khadilkar Bhushan M,
Kulkarni Pushpa R
Publication year - 2002
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.534
Subject(s) - benzaldehyde , biotransformation , chemistry , bioconversion , torulaspora delbrueckii , nuclear chemistry , food science , organic chemistry , catalysis , biochemistry , fermentation , gene , saccharomyces , saccharomyces cerevisiae , enzyme
In a 5 dm 3 stirred tank reactor, bioconversion of 30 g benzaldehyde by cells of Torulaspora delbrueckii yielded 22.9 g of pure L ‐phenylacetylcarbinol ( L ‐PAC). Facile functional group transformation of 4.5 g of L ‐PAC to 2‐(methylimino)‐1‐phenyl‐1‐propanol by exposure to microwave irradiation for 9 min resulted in 2.48 g of product. Conversion of 4.8 g of 2‐(methylimino)‐1‐phenyl‐1‐propanol to 3.11 g of ephedrine was achieved by exposure to microwaves in a reaction time of 10 min. The identity of all the products was confirmed by 1 H NMR and FT‐IR analysis. © 2002 Society of Chemical Industry