Biotransformation of benzaldehyde to  L ‐phenylacetylcarbinol ( L ‐PAC) by  Torulaspora delbrueckii  and conversion to ephedrine by microwave radiation | Zendy

Shukla Vilas B | Zendy; Madyar Virendra R | Zendy; Khadilkar Bhushan M | Zendy; Kulkarni Pushpa R | Zendy

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Biotransformation of benzaldehyde to L ‐phenylacetylcarbinol ( L ‐PAC) by Torulaspora delbrueckii and conversion to ephedrine by microwave radiation

Author(s) -

Shukla Vilas B,

Madyar Virendra R,

Khadilkar Bhushan M,

Kulkarni Pushpa R

Publication year - 2002

Publication title -

journal of chemical technology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.64

H-Index - 117

eISSN - 1097-4660

pISSN - 0268-2575

DOI - 10.1002/jctb.534

Subject(s) - benzaldehyde , biotransformation , chemistry , bioconversion , torulaspora delbrueckii , nuclear chemistry , food science , organic chemistry , catalysis , biochemistry , fermentation , gene , saccharomyces , saccharomyces cerevisiae , enzyme

In a 5 dm 3 stirred tank reactor, bioconversion of 30 g benzaldehyde by cells of Torulaspora delbrueckii yielded 22.9 g of pure L ‐phenylacetylcarbinol ( L ‐PAC). Facile functional group transformation of 4.5 g of L ‐PAC to 2‐(methylimino)‐1‐phenyl‐1‐propanol by exposure to microwave irradiation for 9 min resulted in 2.48 g of product. Conversion of 4.8 g of 2‐(methylimino)‐1‐phenyl‐1‐propanol to 3.11 g of ephedrine was achieved by exposure to microwaves in a reaction time of 10 min. The identity of all the products was confirmed by 1 H NMR and FT‐IR analysis. © 2002 Society of Chemical Industry

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