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Polymeric siRNA delivery vectors: knocking down cancers with polymeric‐based gene delivery systems
Author(s) -
Ardana Aditya,
Whittaker Andrew K.,
McMillan Nigel A.J.,
Thurecht Kristofer J.
Publication year - 2015
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.4508
Subject(s) - small interfering rna , genetic enhancement , gene delivery , cancer , rna interference , cancer therapy , gene silencing , delivery system , medicine , nanotechnology , cancer research , gene , rna , biology , pharmacology , materials science , genetics
One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small‐interfering RNA ( siRNA ) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo , and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy. © 2014 Society of Chemical Industry