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The use of bacteriophages for treatment and prevention of bacterial disease in animals and animal models of human infection
Author(s) -
Barrow P A
Publication year - 2001
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.436
Subject(s) - lytic cycle , disease , antibiotics , human disease , disease control , phage therapy , animal model , intensive care medicine , biology , bacteriophage , microbiology and biotechnology , virology , medicine , escherichia coli , virus , pathology , biochemistry , gene , endocrinology
A brief history of the use of lytic bacteriophages in bacterial disease therapy is presented. After early disillusionment with the idea following poor experimental work, control of phages and field trials, studies were set up in the 1980's in the UK to study their use in farm animal infections. Work with E. coli septicaemia and diarrhoea has shown that phages can be highly effective prophylactically and therapeutically and more effective than antibiotics. There is considerable potential for their use in a limited number of infection types in both man and animals. © 2001 Society of Chemical Industry