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Changing manufacturing paradigms in downstream processing and the role of alternative bioseparation technologies
Author(s) -
Tran Richard,
Lacki Karol,
Davidson Andrew,
Sharma Bhumika,
TitchenerHooker Nigel
Publication year - 2014
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.4234
Subject(s) - biomanufacturing , downstream (manufacturing) , scale (ratio) , downstream processing , biopharmaceutical , emerging technologies , computer science , process (computing) , bioproducts , patent analysis , manufacturing engineering , biochemical engineering , engineering , data science , operations management , microbiology and biotechnology , artificial intelligence , chemistry , biofuel , biochemistry , physics , quantum mechanics , waste management , biology , operating system
BACKGROUND This study ascertains the degree to which bioseparation techniques, considered as alternatives to packed bed chromatography, have been adopted for large‐scale biomanufacturing. Such information will be useful to process engineers interested in investigating the potential of these technologies. RESULTS The results are based on three international industrial surveys distributed to individuals in biomanufacturing in 2006, 2009 and 2012. It yields significant insight to the trends downstream and provides information on which alternative technologies are the most widely adopted as well as those that are the subject of most investigation. The reasons for why particular alternatives have been disregarded for use at scale provide indications of the perceived limitations of these technologies. Details on overall trends in the biopharmaceutical industry, including the types of bioproducts in development and manufacture, the number and size of chromatography steps in downstream processing trains as well as opinions on where the future challenges in biomanufacturing lie are given . CONCLUSIONS The results from the surveys provide insight into how attitudes towards the adoption of alternative purification techniques have changed. There has been an increase in the level of interest and subsequent adoption of alternative technologies encompassing an increasingly wide range of different techniques. © 2013 Society of Chemical Industry