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Biopolymer production in a fed‐batch reactor using optimal feeding strategies
Author(s) -
Lai SongYi,
Kuo PoChih,
Wu Wei,
Jang MingFeng,
Chou YiShyong
Publication year - 2013
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.4067
Subject(s) - polyhydroxyalkanoates , polyhydroxybutyrate , biopolymer , production (economics) , batch production , process engineering , biochemical engineering , process (computing) , pulp and paper industry , batch reactor , productivity , computer science , environmental science , biological system , microbiology and biotechnology , chemistry , engineering , biology , biochemistry , bacteria , polymer , organic chemistry , catalysis , genetics , macroeconomics , economics , operating system
Background Polyhydroxybutyrate ( PHB ), an important member of the family of polyhydroxyalkanoates ( PHAs ), is a biodegradable thermoplastic synthesized by numerous microorganisms under different cultivation conditions . Results A simple dynamic model for producing PHB in a fed‐batch reactor is presented. The kinetic model accuracy is quantified by the specific error measures. The dynamic manipulation scheme with prescribed stepwise changes is used to improve PHB productivity. A multi‐objective optimization algorithm is used to determine the optimal feeding strategy . Conclusion Reduced kinetic models in a mixed culture cultivation process for PHB production are successfully verified. An optimization‐based feeding strategy with stepwise changes has been derived and successfully validated. © 2013 Society of Chemical Industry
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