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Biomimetic fabrication of biocompatible and biodegradable core–shell polystyrene/biosurfactant bionanocomposites for protein drug release
Author(s) -
Hazra Chinmay,
Arunbabu Dhamodaran,
Kundu Debasree,
Chaudhari Ambalal,
Jana Tushar
Publication year - 2013
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.4003
Subject(s) - polystyrene , biodegradation , biocompatibility , emulsion , polyhydroxyalkanoates , polymerization , drug delivery , polymer , bovine serum albumin , chemistry , rhamnolipid , materials science , polymer chemistry , chemical engineering , organic chemistry , chromatography , pseudomonas aeruginosa , biology , bacteria , engineering , genetics
BACKGROUND This paper reports a bioinspired emulsion polymerization approach through biosurfactants (rhamnolipid and surfactin) templating for synthesizing highly monodisperse, spherical polymer bionanocomposites consisting of polystyrene ( PS ) (core)/biosurfactants (shell) (50–190 nm) and their feasibility as a biocompatible and biodegradable drug delivery vehicle.RESULTS Conversion profile, particle size dependence on biosurfactant concentration and structural characterizations of resulting polymers from bioinspired emulsion polymerization were similar to conventional emulsion polymerization. In vitro biodegradation studies revealed >2.5‐fold increase in bacterial growth ( Pseudomonas aeruginosa MTCC 7926) and gravimetric weight loss (10% w/w) in biosurfactants templated PS , compared with the conventional route. Soil burial biodegradation tests supported these findings. In vitro and in viv o biocompatibility studies showed unchanged cell viability of adult rat ( Rattus norvegicus ) hepatocytes for polystyrenes synthesized using biosurfactants, while conventional PS beads proved to be cytotoxic in a dose‐dependent manner. Reactive oxygen species ( ROS )‐induced oxidative stress, increased lipid peroxidation, alterations in GSH detoxification and histopathology corroborated these results. Release of bovine serum albumin ( BSA ) from BSA loaded polystyrene/biosurfactant bionanocomposites were 2.5–5‐fold higher in physiological buffer ( pH 7.4) than in acidic buffer ( pH 1.2).CONCLUSION Taken together, polystyrene/biosurfactant bionanocomposites could serve as a biocompatible and biodegradable colon or intestine‐specific drug delivery vehicle. © 2012 Society of Chemical Industry