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Captopril and its synthesis from chiral intermediates
Author(s) -
Chirumamilla R R,
Marchant R,
Nigam P
Publication year - 2001
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.337
Subject(s) - captopril , chemistry , chemical synthesis , combinatorial chemistry , angiotensin converting enzyme , enantioselective synthesis , enzyme , enantiomer , renin–angiotensin system , stereochemistry , pharmacology , organic chemistry , biochemistry , catalysis , in vitro , medicine , blood pressure
Captopril is an antihypertensive agent that inhibits the angiotensin‐converting enzyme of the renin–angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. © 2001 Society of Chemical Industry