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Penicillin G extraction by amberlite LA‐2—a study of interfacial reaction kinetics by interfacial tension measurements
Author(s) -
Lee Chau Jen,
Wang Shih Sheng
Publication year - 1995
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280640305
Subject(s) - amberlite , kinetics , penicillin , extraction (chemistry) , chemistry , materials science , chromatography , organic chemistry , antibiotics , physics , biochemistry , adsorption , quantum mechanics
The concentration of reactants at an interface cannot be determined directly. The concentration at the interface has been estimated by measuring the interfacial tension at the interface between two immiscible solutions. An aqueous phase, de‐ionised water containing penicillin G, and an organic phase containing amberlite LA‐2 were used as a typical system to study the kinetics of interfacial reaction. The interfacial tension was measured by a spinning‐drop tensiometer at 25 ± 0·1°C. The interfacial tension was found to correlate well with the concentrations of penicillin G, Amberlite, LA‐2 and proton in each respective phase.