Premium
Applicability of continuous membrane bioreactor in production of phenylacetylcarbinol
Author(s) -
Liew Michelle K. H.,
Fane Anthony G.,
Rogers Peter L.
Publication year - 1995
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280640214
Subject(s) - bioreactor , bioconversion , fermentation , dilution , chemistry , biomass (ecology) , membrane bioreactor , industrial fermentation , flux (metallurgy) , yeast , lysis , chromatography , biology , food science , biochemistry , ecology , physics , organic chemistry , thermodynamics
A continuous membrane bioreactor (CMB) with Ceraflo ceramic microfilter was evaluated for the production of phenylacetylcarbinol (PAC) using 12–15 g dm −3 Candida utilis. Compared with the classical continuous fermentation, the CMB process was shown to have higher biomass concentration (from 40% to 400% increase) and greater growth rate (from 3‐ to 9‐fold) at dilution rates varying from 0·03 h −1 . These advantages were partially offset by the reduced permeate flux caused by the increased biomass. Furthermore, an addition of only 3·0 cm 3 h −1 benzaldehyde for 17 h (a typical bioconversion protocol) was found to kill the yeast, resulting in 27% dead organisms and 35% lysed organisms and their associated species. This led to a 100% flux decline during the course of PAC production over the above period.