Premium
Selective manipulation of only one of two similar sites within a molecule ‘odin reactions’: Strategic advantage for synthesis and tactics available
Author(s) -
Milner David J.
Publication year - 1995
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280630402
Subject(s) - sequence (biology) , combinatorial chemistry , computer science , molecule , chemistry , biochemical engineering , nanotechnology , engineering , materials science , organic chemistry , biochemistry
Approaches used to effect selective reaction at one of two or more similar sites in a molecule are reviewed. The nature of the problem is defined and the strategic advantage to be gained through the use of symmetrical intermediates is outlined early and re‐emphasised throughout the discussion with specific examples of multistage syntheses of important products. The various tactics used to effect site selectivity in a late synthetic step are described in a logical sequence and presented in a form aimed to help in the design of syntheses of unsymmetric products from symmetric intermediates.