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Synergistic extraction of penicillin G with aliphatic alcohols and butyl acetate
Author(s) -
Yang ZhiFa,
Yu ShuQiu,
Chen JiaYong
Publication year - 1994
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280610311
Subject(s) - penicillin , extraction (chemistry) , chemistry , ethyl acetate , chromatography , butyl acetate , solvent , hexanol , organic chemistry , alcohol , biochemistry , antibiotics
A solvent mixture of 1‐hexanol and butyl acetate has been successfully used for the extraction of penicillin G. This solvent mixture may not only synergistically and effectively extract penicillin G, but also inhibit emulsion formation during the extraction of penicillin G from the filtrate of the fermentation broth. The equilibrium constants of the extraction, the molar ratios of 1‐hexanol and penicillin G in the extracted species and the synergistic extraction of penicillin G have been studied by chemical analysis and by monitoring the absorbency shift in the FT‐IR spectra of the functional groups in the solvents.