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A simple model for estimating protein solubility in aqueous polymer solutions
Author(s) -
Yu Ming,
de Swaan Arons Jakob,
Smit Jan A. M.
Publication year - 1994
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280600412
Subject(s) - simple (philosophy) , solubility , aqueous solution , polymer , biological system , chemistry , materials science , polymer science , chemical engineering , thermodynamics , organic chemistry , physics , engineering , philosophy , biology , epistemology
A simple scaling analysis of protein solubility in semi‐diluted polymer aqueous solutions was derived based on the recent theoretical development of Abbott et al . 1 on the interactions between protein spheres and entangled polymer coils and the experimental observations of Atha and Ingham 2 on the polymer‐induced protein precipitation. Both the hard‐sphere nature of the protein and the flexibility of the polymer coils have been taken into account in the model. The experimental data can be fitted by using this model with physically reasonable values of the exponent. This approach may be useful in estimating protein solubilities in water in the presence of polymer from limited and usually costly experimental data.