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Enzymatic resolution of 1‐hydroxy‐2,3‐dihydroindene and 1‐hydroxy‐1,2,3,4‐tetrahydronaphthalene derivatives using lipases
Author(s) -
Izumi Taeko,
Murakami Satoshi
Publication year - 1994
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280600105
Subject(s) - transesterification , stereospecificity , chemistry , enzyme , lipase , resolution (logic) , organic chemistry , stereochemistry , catalysis , artificial intelligence , computer science
1‐Hydroxy‐3‐methyl‐2,3‐dihydroindene and 1‐hydroxy‐1,2,3,4‐tetrahydronaphthalene derivatives were kinetically resolved with lipases by transesterification using vinyl esters or butyric anhydride as acyl donors. These results are discussed in considering the influence of acyl donors and with reference to Prelog's proposal that certain enzymes exhibit ‘product stereospecificity’.