Premium
Penicillin G extraction from model media using an emulsion liquid membrane: A theoretical model of product decomposition
Author(s) -
Lee Kwi Ho,
Lee Sang Cheol,
Lee Won Kook
Publication year - 1994
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280590409
Subject(s) - extraction (chemistry) , decomposition , sodium carbonate , emulsion , chromatography , membrane , penicillin , phase (matter) , chemistry , sodium , organic chemistry , biochemistry , antibiotics
To confirm the applicability for the extraction of penicillin G by an emulsion liquid membrane (ELM), the degree of decomposition of penicillin G during extraction was theoretically calculated. Decomposition was less than 1% provided that the initial sodium carbonate concentration in the internal phase was correctly determined, which proved the applicability of the ELM process. The procedure to determine the initial carbonate concentration in the internal phase was also described in order that the pH in the internal phase should be within the relatively stable range for penicillin G at the end of the extraction.