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Synthesis of some novel 2(1H)‐quinazolinones and 2‐thioxo analogues from newly synthesised 1‐acyl‐3‐alkoxyphenylureas and thioureas
Author(s) -
Jaeda Mousa I.,
AbdelSamii Zakaria K.,
Britten A. Z.
Publication year - 1993
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280580413
Subject(s) - chemistry , combinatorial chemistry , elemental analysis , thiourea , organic chemistry , stereochemistry
A convenient route for the synthesis of new 2(1H)‐quinazolinones (IIc—h) and 2(1H)‐quinazolinethiones (IIi—j) is discussed. It involves the cyclodehydration of 1‐acyl‐3‐(alkoxyphenyl)ureas (Ic—h) and the corresponding thioureas (Ii—j) in polyphosphoric acid. Elucidation of structures of the isolated products have been proved in the light of their elemental analysis and spectroscopic data.