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Enzymatic synthesis of (R)‐ and (S)‐2‐cyclohexen‐1‐ol
Author(s) -
Izumi Taeko,
Nakamura Toshihiko,
Eda Yuji
Publication year - 1993
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280570213
Subject(s) - synthon , transesterification , enantioselective synthesis , chemistry , cyclohexanol , organic chemistry , hydrolysis , enzymatic hydrolysis , enzyme , biocatalysis , catalysis , reaction mechanism
The synthetically useful chiral synthons ( R )‐ and ( S )2‐cyclohexen‐1‐ol can be prepared by an enantioselective transesterification of racemic trans‐2‐(phenylseleno) cyclohexanol using lipases, followed by selenoxide elimination and hydrolysis.