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Synthesis of some new 3‐(2′‐heterocyclicethyl)‐2‐methyl‐3,4‐dihydroquinazolin‐4‐one derivatives as antimicrobial agents
Author(s) -
ElZohry Maher F.,
AbdAlla Mohamed A.
Publication year - 1992
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280550303
Subject(s) - chemistry , hydrazine (antidepressant) , sodium ethoxide , phenylhydrazine , ethyl acetoacetate , acetylacetone , thiourea , hydrate , antimicrobial , alkylation , urea , nuclear chemistry , medicinal chemistry , yield (engineering) , hydrazide , proton nmr , organic chemistry , ethanol , catalysis , materials science , chromatography , metallurgy
Abstract 3‐(2′‐Chloroethyl)‐2‐methyl‐3,4‐dihydroquinazolin‐4‐one was reacted with acetylacetone, ethyl acetoacetate and diethylmalonate in the presence of sodium ethoxide to afford the alkylation products IV, V and VI , Compounds IV, V and VI were reacted with hydrazine hydrate, phenylhydrazine, hydroxylamine hydrochloride, urea and thiourea to yield 3‐(2′‐heterocyclicethyl)‐2‐methyl‐3,4‐dihydroquinazolin‐4‐one derivatives VII‐XV . The structures of the synthesized compounds were elucidated by elemental analyses and spectroscopic (IR and XH‐NMR) analyses. The prepared compounds were tested for their antimicrobial activities in comparison with tetracycline as a reference compound.