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Synthesis and application of some new oxazole derivatives as antimicrobial agents
Author(s) -
Bakhite Etify A.,
Mohamed Thana A.,
AbdelRahman Abdu E.
Publication year - 1992
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280550209
Subject(s) - hydrazine (antidepressant) , chemistry , antimicrobial , hydrate , hydroxylamine , hydrazone , oxazole , pyrazoline , reagent , organic chemistry , condensation reaction , combinatorial chemistry , medicinal chemistry , catalysis , chromatography
5‐( p ‐Acetylphenyl)‐2‐phenyloxazole ( I ) was condensed with aromatic aldehydes to furnish chalcones 2a‐e . Cyclocondensation of 2a‐e with hydrazine hydrate and with phenyl hydrazine led to the formation of pyrazoline derivatives 3a‐e and 4a‐e respectively. Similarly, 2a was interacted with hydroxylamine to give isoxazoline ( 5 ). On the other hand, condensation of 1 with phenyl hydrazine yielded hydrazone 6 which on treatment with Vilsmeier reagent (DMF/POCl 3 ) gives 5‐[ p ‐(4‐formyl‐1‐phenylpyrazol‐3‐yl)phenyl]‐2‐phenyloxazole ( 7 ). Also, a few derivatives of 7 have been prepared. Moreover, all compounds were screened for their antimicrobial activity against some strains of bacteria and fungi.