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Synthesis and application of some new heterocyclo‐5‐sulphonyl‐8‐hydroxyquinolines as antimicrobial agents
Author(s) -
Hafez Ali A. Abdel,
Awad Ibrahim M. A.,
ElZohry Maher F.
Publication year - 1992
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280540410
Subject(s) - malononitrile , antimicrobial , chemistry , chelation , condensation , gram , nuclear chemistry , in vitro , pyrazoline , combinatorial chemistry , metal , bacteria , organic chemistry , biochemistry , catalysis , biology , physics , genetics , thermodynamics
A new series of 5‐sulphonyl‐(‐nicotinonitriles, pyridones and cyclohexenones)‐8‐hydroxyquinolines 2, 3 and 4 have been synthesised by Michael condensation of 5‐sulphonyl‐(4′‐arylidino‐3‐methyl‐2‐pyrazoline‐5‐one)‐8‐hydroxyquinoline 1 with malononitrile, ethylcyanoacetate and ethylacetoacetate respectively. The metal chelates for compounds 2 and 3 with Cu 2+ Hg 2+ and Fe 3+ have been synthesised. All the prepared compounds were screened in vitro with some selected Gram‐positive and Gram‐negative bacteria.