Synthesis and application of novel sulpha drugs based on quinoxaline‐2‐one and/or quinoxaline‐2‐thione

Some novel azo‐Sulpha drugs as 3‐methyl‐ N ‐azo‐(4′‐substituted heterocyclo‐benzene‐sulphamoyl) quinoxaline‐2‐ones (1‐11) and 3‐methyl‐ N ‐azo‐(4′‐substituted heterocyclo‐benzene‐sulphamoyl)‐quinoxaline‐2‐thiones (1′–11′) were synthesized by coupling 4′‐substituted heterocyclo‐benzene‐sulphamoyl diazonium acetates with 3‐methyl‐ N ‐(1H)‐quinoxaline‐2‐one and/or with 3‐methyl‐ N (1H) quinoxaline‐2‐thione in acid medium. The corresponding iron (III) (1a‐11, 1′a‐11′a) copper (II) (1b‐1b′‐7b′) and mercury (II) (1c‐11c, 1c′‐11c) chelates were also prepared in a 1:1 metal‐to‐ligand ratio. The ligands and their chelates were characterized on the basis of microanalysis, UV, IR and H'‐NMR spectrometry and were tested in vitro for their antibacterial and antifungal activities.