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Synthesis and application of novel sulpha drugs based on quinoxaline‐2‐one and/or quinoxaline‐2‐thione
Author(s) -
Awad Ibrahim M. A.
Publication year - 1992
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280530303
Subject(s) - quinoxaline , chelation , chemistry , benzene , medicinal chemistry , ligand (biochemistry) , nuclear chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry
Some novel azo‐Sulpha drugs as 3‐methyl‐ N ‐azo‐(4′‐substituted heterocyclo‐benzene‐sulphamoyl) quinoxaline‐2‐ones (1‐11) and 3‐methyl‐ N ‐azo‐(4′‐substituted heterocyclo‐benzene‐sulphamoyl)‐quinoxaline‐2‐thiones (1′–11′) were synthesized by coupling 4′‐substituted heterocyclo‐benzene‐sulphamoyl diazonium acetates with 3‐methyl‐ N ‐(1H)‐quinoxaline‐2‐one and/or with 3‐methyl‐ N (1H) quinoxaline‐2‐thione in acid medium. The corresponding iron (III) (1a‐11, 1′a‐11′a) copper (II) (1b‐1b′‐7b′) and mercury (II) (1c‐11c, 1c′‐11c) chelates were also prepared in a 1:1 metal‐to‐ligand ratio. The ligands and their chelates were characterized on the basis of microanalysis, UV, IR and H'‐NMR spectrometry and were tested in vitro for their antibacterial and antifungal activities.