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Synthesis and anti‐inflammatory activity of some novel 1,3,4‐oxadiazole derivatives
Author(s) -
ElSamii Z. K. Abd
Publication year - 1992
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280530206
Subject(s) - oxadiazole , triazine , phenylbutazone , chemistry , anti inflammatory , combinatorial chemistry , organic chemistry , pharmacology , medicine
Some novel 1,3,4‐oxadiazoline and 1,3,4‐oxadiazole derivatives have been synthesized from 3‐hydroxy‐5,6‐diphenyl‐1,2,4‐triazine. Illucidation of the structures of the isolated products has been proved in the light of their elemental analysis, spectroscopic data and unambiguous synthesis in certain cases. Some derivatives have shown promising anti‐inflammatory activity in comparison to phenylbutazone.