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The loss of substrate from a vial during freeze‐drying using escherichia coli as a trace organism
Author(s) -
Adams Gerald D. J.
Publication year - 1991
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280520408
Subject(s) - vial , ablation , substrate (aquarium) , freeze drying , contamination , materials science , escherichia coli , chromatography , chemistry , biomedical engineering , biology , medicine , ecology , biochemistry , gene
The potential for ablation during product freeze‐drying has been assessed using a defined area surrounding the processed vial. This technique has enabled media formulations to be compared. The paper suggests ways in which the mini‐chambers may be used to investigate the extent of ablation and methods for reducing contamination of a freeze‐drier by ablation.