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Premium Synthesis and application of some new heterocyclo‐s‐triazole derivatives as antimicrobial agents
Author(s)
Awad Ibrahim M. A.,
AbdelRahman AbduE,
Bakite Etify A.
Publication year2007
Publication title
journal of chemical technology and biotechnology
Resource typeJournals
PublisherJohn Wiley & Sons
Abstract 3‐Aryloxymethyl‐4‐amino‐5‐mercapto‐s‐triazoles (1 a–c ) reacted with alkyl/aralkyl halides to give 5‐alkyl/aralkyl thio‐s‐triazole derivatives (2 a–i ) and with substituted phenacyl bromides afforded s‐triazolo‐thiadiazines (3 a–l ). Condensation of 1 a–c with aromatic/heterocyclic aldehydes furnished the corresponding schiff bases 4 a–r . The latter compounds (4 b,h,n ) were further reacted according to Mannich reaction affording 5 a–f and 6 a–c . Moreover, interaction of 4 b,h,n with phenacyl bromides yielded the bicyclic compounds 7 a–l . Some of these compounds were screened in vitro for their antimicrobial activity against seven strains of bacteria.
Subject(s)1,2,4 triazole , alkyl , antimicrobial , catalysis , chemistry , combinatorial chemistry , halide , mannich reaction , medicinal chemistry , organic chemistry , phenacyl , phenacyl bromide , thio , triazole
Language(s)English
SCImago Journal Rank0.64
H-Index117
eISSN1097-4660
pISSN0268-2575
DOI10.1002/jctb.280510406

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