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Synthesis of some new 7‐substituted aminomethyl‐6‐chloroquinoline‐5,8‐quinones
Author(s) -
Yanni A. S.,
Khalil Z. H.
Publication year - 1991
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280510107
Subject(s) - morpholine , chemistry , piperidine , quinone , paraformaldehyde , alkyl , aryl , organic chemistry , ethanol , medicinal chemistry
Some new 7‐alkyl (or aryl) aminomethyl‐6‐chloroquinoline‐5,8‐quinones ( II ) have been obtained through the reaction of 6‐chloroquinoline‐5,8‐quinone with primary aliphatic or aromatic amines and paraformaldehyde in ethanol. On using secondary amines such as piperidine or morpholine in the above reaction, 6‐chloro‐7‐piperidino (or morpholino) methylquinoline‐5,8‐quinone ( III ) and ( IV ) respectively were obtained. The structure of the synthesised compounds was confirmed by elemental analysis and spectral data. The synthesised compounds were also biologically evaluated.