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A mechanistic growth model of a methylotroph
Author(s) -
Agrawal Pramod,
Lim Henry C.
Publication year - 1990
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280470404
Subject(s) - methylotroph , formaldehyde , methanol , growth model , biological system , chemistry , biochemical engineering , biology , biochemistry , engineering , mathematics , organic chemistry , mathematical economics
Based on the biochemical knowledge of the RMP‐cycle methylotrophs and the experimental results of batch and continuous culture growth of a methylotroph, L3, a simple mechanistic growth model of L3 was developed. The growth model consists of a basic structure and a regulatory structure. The basic‐model structure was developed by incorporating formaldehyde as a state variable and including a lpump‐and‐leak' mechanism of formaldehyde transport. The regulatory‐model structure was built by acknowledging growth inhibition due to formaldehyde and formaldehyde inhibition of methanol oxidation. The resulting model describes adequately the batch as well as the stable and unstable steady‐state continuous culture behavior of L3 on mixtures of methanol and formaldehyde.