Premium
Effect of nitrous acid on antipyrine. II. Synthesis of fluoro‐organic derivatives
Author(s) -
AbdAlla Mohamed A.,
Atta Ferial M.,
AbdElmonem Maisa E.,
Metwally Saoud A.
Publication year - 1988
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280430202
Subject(s) - nitrous acid , chemistry , sodium nitrite , pyrolysis , nitrous oxide , sodium , nitrite , inorganic chemistry , organic chemistry , nuclear chemistry , medicinal chemistry , nitrate
Interaction of antipyrine (I) with nitrous acid in the presence of excess sodium nitrite as buffer, followed by the addition of fluoroboric acid afforded the direct and short way to synthesis of antipyrine‐4′‐diazonium fluoroborate (II). Pyrolysis of (II) at 165°C gave 4′‐fluoroantipyrine (III). The structure of (III) was determined by IR and 13 C NMR analyses.