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A new route to 4‐, 5‐, and 6‐indolecarboxylic acids
Author(s) -
Kasahara Akira,
Izumi Taeko,
Yanai Hiroshi,
Murakami Satoshi,
Takatori Masayuki
Publication year - 1986
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280361204
Subject(s) - indole test , ring (chemistry) , halogen , benzene , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl
There are many indole derivatives bearing carboxyl or methoxycarbonyl groups on the benzene ring and these often have patent physiological activities. Synthesis of these compounds usually starts from indoles having a halogen group at the desired position on an indole ring. We now report a facile synthesis of 4‐, 5‐, and 6‐indolecarboxylic acids from 2‐bromoaniline derivatives ( 1 ). The synthetic route is shown in Figure 1.