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Liquid phase oxidation of acetophenone to phenylglyoxal by selenium dioxide alone or with aqueous nitric acid
Author(s) -
Sharma Virendra K.,
Chandalia Sampatraj B.
Publication year - 1986
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.280361004
Subject(s) - phenylglyoxal , acetophenone , chemistry , nitric acid , selenium , inorganic chemistry , catalysis , solvent , aqueous solution , organic chemistry , nuclear chemistry , biochemistry , amino acid , arginine
The liquid phase oxidation of acetophenone to phenylglyoxal using selenium dioxide was carried out at 90°C in dioxane or ethyl alcohol with 10% (v/v) of water as a solvent with a 2:1 molar ratio of acetophenone to selenium dioxide. The yield of phenylglyoxal was more than 98% based on acetophenone and the efficiency of utilisation of selenium dioxide was as high as 99%. A novel process version based on the oxidation of acetophenone by aqueous nitric acid in the presence of selenium dioxide as a selective catalyst in a redox cycle was also considered with a view to changing the use of selenium dioxide as a stoichiometric oxidising agent to that of a catalyst, and it was found to be attractive.